Drug Therapies Used in Parkinson’s Disease

A group of people with Parkinson’s disease was surveyed and asked what medications they take to treat the disease. If you ever questioned whether this disease is unique in terms of symptoms, just read this list of medications approximately 20 people with Parkinson’s have used or are currently using to treat the symptoms associated with PD. Also, notice the variance of the drugs used to treat depression in PD. Depression is not just a real illness in and of itself, but combined with PD, it can be frightful and very difficult to cope with.

If you are struggling with depression to any degree, let your doctor know right away. It affects every aspect of life.

Drugs used to treat Parkinson’s disease and its symptoms:

  • Nuplazid – first drug to treat hallucinations and delusions associated with Parkinson’s disease
  • Mertazopine – antidepressant
  • Seroquel – It can treat schizophrenia, bipolar disorder, and depression.
  • Carbodopa/Levodopa – primarily used to manage the symptoms of Parkinson’s disease but does not change the course of the disease (aka Parcopa and Sinemet)
  • Mybetrig – for the treatment of overactive bladder
  • Respiridone – (aka Respirdol) It can treat schizophrenia, bipolar disorder, and irritability caused by PD
  • Lexapro – antidepressant
  • Ativan – used to treat anxiety disorders, trouble sleeping
  • Rytary Neuropatch – a combination of carbidopa and levodopa for the treatment of Parkinson’s disease
  • Azilect – used as a monotherapy to treat symptoms in early Parkinson’s disease
  • Mirapex – treats Parkinson’s disease and restless legs syndrome
  • Domperidone – used to relieve nausea and vomiting; to increase the transit of food through the stomach
  • Ropinerole – a dopamine agonist, used in the treatment of Parkinson’s disease and restless legs syndrome (RLS)
  • Aricept – treats Alzheimer’s disease
  • Clonozopin – treats seizures, panic disorder, and anxiety
  • Zoloft – antidepressant
  • Endacapone – used to treat PD
  • Stalevo – three medicines – levodopa, carbidopa and entacapone. They work together to increase the levels of dopamine in the brain. Used to treat Parkinson’s disease
  • Amantadine – treats Parkinson’s disease and parkinson-like symptoms caused by certain medications
  • Linzess – used as a laxative
  • Alprazalam – used for the treatment of anxiety disorders, especially of panic disorder, but also in the treatment of generalized anxiety disorder (GAD) or social anxiety
  • Gabepentin – Nerve pain medication; restless leg syndrome; chronic pain;
  • Oxycodone – treats moderate to severe pain
  • Exelon patch – can treat dementia
  • Cymbalta – It can treat depression, anxiety, diabetic, and chronic muscle or bone pain

Supplements:

  • Magnesium – Magnesium is a mineral that acts as a natural relaxant. Some indications of deficiency are: muscle tremors or spasm, muscle weakness, insomnia or nervousness, high blood pressure, irregular heartbeat, constipation, hyperactivity, depression. Magnesium’s role in supporting good sleep may also be quite important here, since many people with Parkinson’s experience poor sleep patterns.
  • Vitamin B12 – Researchers concluded that low B12 status may be a risk factor for greater morbidity in Parkinson’s, and efforts to prevent or correct the deficiency should be undertaken to possibly slow the onset of disability in Parkinson’s disease. (Christine C et al. Abstract S411. Presented at: American Neurological Association Annual Meeting 2015. September 27-29, 2015; Chicago.)
  • Vitamin D – Researchers report that there is a correlation between insufficient levels of vitamin D and the development of early Parkinson’s disease.
  • Omega 3 – The omega-3’s are anti-inflammatory which may be beneficial as neuro-inflammation is a feature of Parkinson’s. Mood problems are also a common feature and there has been a lot of research into the mood-boosting properties of the omega-3 essential fats. A small placebo-controlled pilot trial reported significantly greater improvement of depression in Parkinson’s patients treated with omega-3 fatty-acid supplementation versus placebo. The richest dietary source is from fish such as salmon, mackerel, herring, sardines, trout, pilchards and anchovies.

 

 

Singing Over Us

IMG_5329Almost every day I enjoyed the privilege of putting my granddaughter down for her nap. Sometimes we read a book (or two or three). Sometimes I sang to her. Sometimes, both.

I used to struggle with the verse, “The LORD your God is with you, he is mighty to save. He will take great delight in you, he will quiet you with his love, he will rejoice over you with singing.” Zeph 3:17

Not anymore. Not since singing my little Clara to sleep. For some reason, when I began to sing to her, she stopped fussing. She put her head down on my shoulder and listened. I cold feel her body relax and she would close her eyes and soon (sometimes later than sooner) be  asleep. Sometimes I would think she was asleep and when I began to move her to put her in bed, in a sleepy voice she wold say, “Keep singing, Grammie.”

And so, I did.

I was talking to a friend not long ago. A friend who has Parkinson’s disease and who was struggling. We do that every now and then, you know – struggle. I was trying to encourage her fraught spirit and we started talking about the verse above from the book of Zephaniah. I told her what I’ve told you thus far. Then I told her what God has taught me through singing to little Clara.

God tells us that He is with us. He has told us that He will never leave us – in our weariness, when we are burdened, weighed down, under pressure, stressed, under attack – you know – just plain wiped out physically, emotionally, mentally, spiritually. He has the strength and desire to save us from all that begs to destroy our well-being. Why? He delights in us. He derives pleasure in taking care of us. It brings Him joy and gladness. He revels in doing things – just for us.

He will quiet you with His love… When Clara would lay her head down, I would rub her back and sing to her. She knew she was loved. A child will have difficulty falling asleep when they do not feel safe or loved and they feel safe when they know they are loved.

We are no different. We feel safe when we know that we are loved. We are able to rest – to lean into the Lord and let go of all the things that this life can throw at us. We can rest our head on His shoulder and know He will take care of us and in that, we find comfort and peace.

He will rejoice over you with singing… What a picture this brings to mind. A newborn baby – being cradled in her daddy’s arms as he sings over her with an inexplicable love and inexpressible joy. This is how God looks upon His children and that blows me away. He knows us each by name and loves us with a love that is so unfathomable, we cannot comprehend it. He rejoices over us and delights in us with singing, as a new daddy with his precious newborn.

I don’t know about you, but that makes me smile. It also makes me sleep just a bit more peacefully.

Does My Life Matter?

Green_Dogwood.JPGSometimes I don’t know if it’s me or if it’s me with Parkinson’s that causes me to dwell on death at times. I sometimes think ‘today is the day it will end.’ The day it will all be over.

Is it just me? Is it the disease? Is it me with the disease?

I watch a video of a man who, as he pans and photographs the Hawaiian coast with his drone, asks the question over and over, “Does your life matter?” I sit and watch as the drone flies over alcoves of paradise and his constant question causes me to wonder, does my life matter? Has my life mattered?

The drone skims the water, rushing upon every hue of green that is scattered upon the island foliage.

Does my life matter? The thought whispers into my brain again. Has it mattered at all?

Somehow, I ran across Davis Phinney’s site. Phinney was an Olympic Bronze Medalist in the 1984 Olympic games. Phinney has Parkinson’s disease. His ‘slogan’ for his foundation is, ‘Live Well Today’.

Live well today. TODAY stands out to me like a flashing light. It’s not a question of if my life has mattered. All that matters is today. Yes, I want my life to have mattered. I want to live today so that my life didn’t just take up space, but made a difference. I can live with the fact that life is short and this may very well be my last day, but I find it difficult to live knowing that someday I will stand before my maker, aware of what I needed to do or could have done to make a difference but neglected to or chose not to do it.

It is often easy for me to get caught up in a ‘do good’ mentality, thinking all the good I do will please God, but there is no merit that can satisfy God. It is not works that save me, but grace. I matter not because of what I have done or will do, but only because of what has already been done by Christ on the cross.

So, yes, my life matters but I need to remember that it good things, good works, good deeds – they’re all good, but they are worth nothing without Christ.